In No More- a story arc starting in Peter Parker: The Spectacular Spider-Man #303- a trip to the past to retrieve vital information resulted in Peter Parker changing his past when his younger self decided to abandon being Spider-Man because he felt, based on what he had seen and overheard of his future self's life, that such a career would only bring him pain and suffering. As a result, Peter Parker became a successful industrialist married to Gwen Stacy, but Norman Osborn has conquered the world, killing Iron Man and most of the Fantastic Four and imprisoning Doctor Doom, with Peter still hiding behind his corporate role even as Gwen discreetly aids the resistance as he believes that taking action as Spider-Man will only make things worse.
To fight the deranged villain known as Massacre, Peter built himself a dark colored bulletproof armored costume that deflects bullets, and equipped himself with magnetic webbing that can be used to disable the radio frequencies of Massacre's charges. It is also lightweight, but needs to recharge after a certain period of usage. Peter has also incorporated the technology in improving road safety.
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When Peter learns that his old enemy the Rhino is on a rampage in Times Square, he suits up as Spider-Man to stop the destructive villain in his tracks. But he's unexpectedly foiled in his attempts by the Black Cat, a former ally and old flame. The Cat informs Peter that the Rhino is just a distraction -- the real threat comes from a group of Ancients, members of the same race as the being called Morlun, who Spidey defeated in battle years earlier. The Ancients are now looking to exact revenge -- and hope to steal Spider-Man's life force in the process.
The letters page for US Marvel Comics issue #64 declared The Transformers and Marvel Universes to be separate. In the process, it politely asked the readers to just forget about the issue guest-starring Spider-Man. But the Wiki never forgets. The Marvel Database wiki notes that the Spider-Man from the issue therefore appears to be a paradox, as he has memories of events of the mainstream "616" universe, but lives in a realm where few 616 heroes and villains exist.